![]() ![]() The risk is greater in people with kidney disease, anemia, diabetes, electrolyte imbalance, vitamin B deficiency, or with chronic debilitating diseases. Long-term use has also been associated with peripheral neuropathy (nerve disease or damage particularly confined to the feet or hands).Periodic liver enzyme monitoring may be needed. May cause liver problems, particularly with long-term use.Should not be taken again by people who have had liver problems or reactions to nitrofurantoin in the past.Urine samples should be taken both before and after treatment. Because the distribution of nitrofurantoin to other tissues is limited, there is a higher chance that the bacterial infection being treated may persist or recur.Do not use to treat pyelonephritis or perinephric abscesses.Do not use in people with a previous history of liver dysfunction or cholestatic jaundice associated with nitrofurantoin use, or with previous hypersensitivity to nitrofurantoin. ![]() Contraindicated in people with significantly impaired kidney function (creatinine clearance less than 60mL per minute or significantly elevated creatinine), oliguria, or anuria because of the increased risk of toxicity because of impaired excretion of nitrofurantoin.The risk is greater in people receiving nitrofurantoin for longer than six months. ![]() If these develop, nitrofurantoin should be discontinued. Nitrofurantoin has been associated with potentially fatal lung conditions such as interstitial pneumonitis and pulmonary fibrosis.Other side effects, such as abdominal pain, constipation, diarrhea, skin reactions, or cardiovascular effects are uncommon or relatively rare. Nausea or vomiting, changes in facial skin color, dark-colored urine, flatulence, headache, and weight loss. ![]() If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: However, some bacteria are not susceptible to nitrofurantoin and care should still be taken not to encourage the development of resistant bacteria.
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